tafluprost

Ligand id: 7451

Name: tafluprost

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 75.99
Molecular weight 452.24
XLogP 5.36
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Approved as an ocular formulation to treat open-angle glaucoma or other causes of increased pressure inside the eye.
Mechanism Of Action and Pharmacodynamic Effects
Tafluprost is a fluoridated analogue of prostaglandin F2α and as such is a selective FP receptor agonist [1], although note that tafluprost acid is the active metabolite. The tafluprost ester facilitates corneal penetration and allows delivery of the active carboxylic acid form to the aqueous humour . It is believed that tafluprost acid increases outflow of aqueous humour from the eye, thereby reducing intraocular pressure and relieving the symptoms of glaucoma.