Ligand id: 7451

Name: tafluprost

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View more information in the IUPHAR Pharmacology Education Project: tafluprost

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 75.99
Molecular weight 452.24
XLogP 5.36
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Bioactivity is attributed to the active metabolite, tafluprost acid. EC50 for tafluprost acid at the human prostanoid FP receptor is 0.53nM [1].
Selectivity at GPCRs
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Target Sp. Type Action Affinity Units Concentration range (M) Reference
FP receptor Hs Agonist Agonist - - - 1