tafluprost

Ligand id: 7451

Name: tafluprost

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 75.99
Molecular weight 452.24
XLogP 5.36
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Bioactivity is attributed to the active metabolite, tafluprost acid. EC50 for tafluprost acid at the human prostanoid FP receptor is 0.53nM [1].
Selectivity at human GPCRs
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Target Type Action Affinity Units Concentration range (M) Reference
FP receptor Agonist Agonist - - - 1
[1]