ulipristal acetate

Ligand id: 7460

Name: ulipristal acetate

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 63.68
Molecular weight 475.27
XLogP 4.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Approved uses: ulipristal acetate is indicated for pre-operative treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age and as an emergency contraceptive (to be taken within 120 hours of unprotected sex or contraceptive failure).
Mechanism Of Action and Pharmacodynamic Effects
Ulipristal acetate is a progesterone receptor modulator. It has partial agonist and antagonist activity at the progesterone receptor [1]. Use of the drug delays ovulation and inhibits maturation of the uterine endometrium meaning that implantation is less likely.
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