bufexamac

Ligand id: 7498

Name: bufexamac

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 58.56
Molecular weight 223.12
XLogP 2.28
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Bufexamac is a non-steroidal anti-inflammatory drug (NSAID). This drug was used to control the symptoms of inflammation of the skin (such as redness and itching) in diseases such as eczema and dermatitis. Howerver, the EMA revoked marketing authorisation for medicines containing bufexamac throughout the European Union in 2010 due to an unacceptable risk of developing contact dermatitis. Other countries may still approve use of this drug.
Mechanism Of Action and Pharmacodynamic Effects
This drug was originally believed to primarily be a cyclooxygenase (COX) inhibitor, although its precise MMOA remains unclear [2]. More recently, bufexamac has been discovered to inhibit HDACs 6 and 10, and subsequently inhibit IFN-α secretion [1], which may contribute to its anti-inflammatory action.