Ligand id: 7555

Name: modafinil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 79.37
Molecular weight 273.08
XLogP 3.3
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
May be used to treat excessive sleepiness associated with narcolepsy, obstructive sleep apnea and shift work disorder [2].
Mechanism Of Action and Pharmacodynamic Effects
One of the mechanisms by which modafinil is proposed to operate, is as an atypical dopamine reuptake inhibitor [7]. This action would increase dopamine levels in the brain and thereby promote wakefulness. The involvement of other mechanisms is reviewed in these two articles: [3] and [5].
External links