modafinil   Click here for help

GtoPdb Ligand ID: 7555

Synonyms: Provigil®
Approved drug
modafinil is an approved drug (FDA (1998))
Compound class: Synthetic organic
Comment: Modafinil is a eugeroic (wakefulness-promoting) drug with a multi-faceted mechanism of action. In some jurisdictions this drug is classified as a controlled substance due to its possible addiction potential. It has been termed a 'smart' drug, a group of prescription medications, purchased illegally or used off-label, with alleged cognition-enhancing properties [1,4].
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species

modafinil is commercially available from our sponsors

2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 79.37
Molecular weight 273.08
XLogP 0.61
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
Isomeric SMILES NC(=O)CS(=O)C(c1ccccc1)c1ccccc1
InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
InChI Key YFGHCGITMMYXAQ-UHFFFAOYSA-N
References
1. Dance A. (2016)
Smart drugs: A dose of intelligence.
Nature, 531 (7592): S2-3. [PMID:26934523]
2. Erman MK, Rosenberg R, Modafinil Shift Work Sleep Disorder Study Group. (2007)
Modafinil for excessive sleepiness associated with chronic shift work sleep disorder: effects on patient functioning and health-related quality of life.
Prim Care Companion J Clin Psychiatry, 9 (3): 188-94. [PMID:17632651]
3. Gerrard P, Malcolm R. (2007)
Mechanisms of modafinil: A review of current research.
Neuropsychiatr Dis Treat, 3 (3): 349-64. [PMID:19300566]
4. Hawkes N. (2015)
Modafinil does enhance cognition, review finds.
BMJ, 351: h4573. [PMID:26296947]
5. Minzenberg MJ, Carter CS. (2008)
Modafinil: a review of neurochemical actions and effects on cognition.
Neuropsychopharmacology, 33 (7): 1477-502. [PMID:17712350]
6. Zhou J, He R, Johnson KM, Ye Y, Kozikowski AP. (2004)
Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization.
J Med Chem, 47 (24): 5821-4. [PMID:15537337]
7. Zolkowska D, Jain R, Rothman RB, Partilla JS, Roth BL, Setola V, Prisinzano TE, Baumann MH. (2009)
Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil.
J Pharmacol Exp Ther, 329 (2): 738-46. [PMID:19197004]