methylnaltrexone

Ligand id: 7563

Name: methylnaltrexone

Abbreviated name: MNTX

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 66.76
Molecular weight 356.19
XLogP 0.54
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat the constipation caused by opioid analgesics, when the response to other laxatives has been insufficient. This is principally used for terminal patients receiving high dose pain relief, but may also be used in other patient groups [1].
Mechanism Of Action and Pharmacodynamic Effects
Acts as an antagonist at μ opioid receptors in the gut, blocking the activity of other opioid drugs in the gut without affecting their analgesic activity in the brain. This helps to reduce opioid-induced constipation.
External links