Ligand id: 7563

Name: methylnaltrexone

Abbreviated name: MNTX

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 66.76
Molecular weight 356.19
XLogP 0.54
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
μ receptor Hs Antagonist Antagonist 8.7 pKi - 2
pKi 8.7 (Ki 2x10-9 M) [2]
Description: Displacement of [3H]DAMGO from human μ opioid receptors expressed in CHO cells
κ receptor Hs Antagonist Antagonist 8.2 pKi - 2
pKi 8.2 (Ki 6.3x10-9 M) [2]
δ receptor Hs Antagonist Antagonist 6.1 pKi - 2
pKi 6.1 (Ki 9x10-7 M) [2]