methylnaltrexone

Ligand id: 7563

Name: methylnaltrexone

Abbreviated name: MNTX

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 66.76
Molecular weight 356.19
XLogP 0.54
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Li Z, Pergolizzi JV, Huttner RP, Zampogna G, Breve F, Raffa RB. (2015)
Management of opioid-induced constipation in pregnancy: a concise review with emphasis on the PAMORAs.
J Clin Pharm Ther,  [Epub ahead of print]. [PMID:26573866]
2. Wentland MP, Lou R, Lu Q, Bu Y, Denhardt C, Jin J, Ganorkar R, VanAlstine MA, Guo C, Cohen DJ et al.. (2009)
Syntheses of novel high affinity ligands for opioid receptors.
Bioorg. Med. Chem. Lett.19 (8): 2289-94. [PMID:19282177]