Ligand id: 7680

Name: AZD1981

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 96.63
Molecular weight 388.06
XLogP 3.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
AZD1981 is an antagonist of the prostanoid DP2 receptor and as such blocks the action of prostaglandin D2 at this receptor. The aim of blocking DP2 receptor function is to reduce cellular infiltration in airway tissues, which leads to a decrease in the airway inflammation implicated in asthma pathogenesis.