Ligand id: 7680

Name: AZD1981

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 96.63
Molecular weight 388.06
XLogP 3.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Immunopharmacology Comments
AZD1981 acts as an antagonist of the GPCR, DP2 (a.k.a. CRTH2) expressed by Th2 lymphocytes and eosinophils. This mechanism would be expected to inhibit prostaglandin D2-driven chemotaxis.
Immunopharmacology Disease
Disease X-Refs Comment References
Asthma Disease Ontology: DOID:2841
OMIM: 600807
Phase 2 clinical candidate with predicted anti-asthmatic activity (see NCT00758589 for example). Has alos completed Phase 2 clinical trials for COPD (NCT00690482) and chronic idiopathic urticaria (NCT02031679).