Ligand id: 7687

Name: AZD6703

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 55.89
Molecular weight 417.22
XLogP 2.76
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
AZD6703 was investigated as a potential treatment for inflammatory diseases such as osteoarthritis.
Mechanism Of Action and Pharmacodynamic Effects
AZD6703 is an inhibitor of p38a MAP kinase (MAPK14). p38α mitogen-activated protein kinase (MAPK) is critical for the regulation of pro-inflammatory cytokines such as tumour necrosis factor alpha (TNF-α) and interleukin-1β (IL-1β). Over production of these cytokines is linked to the inflammatory processes driving a broad range of diseases including rheumatoid arthritis, psoriasis, inflammatory bowel disease, multiple sclerosis, ischaemia [2], Alzheimer's disease, and neuropathic pain [3-4].