Ligand id: 7687

Name: AZD6703

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 55.89
Molecular weight 417.22
XLogP 2.76
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Brown DS, Cumming JG, Bethel P, Finlayson J, Gerhardt S, Nash I, Pauptit RA, Pike KG, Reid A, Snelson W et al.. (2012)
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.
Bioorg. Med. Chem. Lett., 22 (12): 3879-83. [PMID:22608965]
2. Clark JE, Sarafraz N, Marber MS. (2007)
Potential of p38-MAPK inhibitors in the treatment of ischaemic heart disease.
Pharmacol. Ther., 116 (2): 192-206. [PMID:17765316]
3. Saklatvala J. (2004)
The p38 MAP kinase pathway as a therapeutic target in inflammatory disease.
Curr Opin Pharmacol, 4 (4): 372-7. [PMID:15251131]
4. Schieven GL. (2005)
The Biology of p38 Kinase: A Central Role in Inflammation.
Current Topics in Medicinal Chemistry, 5 (10): 921-928.