Ligand id: 7820

Name: AZD1386

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 78.51
Molecular weight 423.06
XLogP 4.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
AZD1386 was investigated in clinical trial as an analgesic [2] to treat chronic or neuropathic pain, and to reduce esophageal pain/sensitivity in patients with gastroesophageal reflux disease (GERD, see Phase II trial number NCT01019928)
Mechanism Of Action and Pharmacodynamic Effects
Inhibition of TRPV1 is hypothesised to reduce nociceptive activity, especially in inflammatory conditions.