Ligand id: 7826

Name: AZD9056

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 61.36
Molecular weight 418.24
XLogP 5.48
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
AZD9056 was developed for the treatment of inflammatory conditions such as rheumatoid arthritis (RA), chronic obstructive pulmonary disease (COPD) and Crohn’s disease. Phase II trial NCT00520572 for RA has been completed. There are no active trials in progress (Nov 2014).
Mechanism Of Action and Pharmacodynamic Effects
The molecular mechanism of action of P2X7 receptor antagonism in rheumatoid disease is reviewed by McInnes et al. (2014) [1].