Ligand id: 7857

Name: sacubitril

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 13
Topological polar surface area 92.7
Molecular weight 411.2
XLogP 6.97
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
In July 2015, the US FDA approved the fixed-dose combination Entresto® (sacubitril plus valsartan, PubChem CID 24755604) to treat heart failure. Entresto® is reported to be superior to enalapril in reducing the risks of death and hospitalization for heart failure [1].