Ligand id: 7953

Name: BMS-777607

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 106.78
Molecular weight 512.11
XLogP 4.63
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
A single Phase II clinical trial for advanced or metastatic solid tumors (NCT00605618) has been completed. Development has not progressed beyond Phase II.
Mechanism Of Action and Pharmacodynamic Effects
Inhibition of hepatocyte growth factor (HGF) binding to c-MET disrupts the MET signaling pathway and this may induce cell death in tumour cells driven by c-MET.