BMS-777607

Ligand id: 7953

Name: BMS-777607

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 106.78
Molecular weight 512.11
XLogP 4.63
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxopyridine-3-carboxamide
Synonyms
BMS 777607 | BMS777607
Database Links
CAS Registry No. 1196681-44-3
ChEMBL Ligand CHEMBL460702
GtoPdb PubChem SID 249565636
PubChem CID 24794418
RCSB PDB Ligand 353
Search Google for chemical match using the InChIKey VNBRGSXVFBYQNN-UHFFFAOYSA-N
Search Google for chemicals with the same backbone VNBRGSXVFBYQNN
Search UniChem for chemical match using the InChIKey VNBRGSXVFBYQNN-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone VNBRGSXVFBYQNN
Comments
BMS-777607is a selective and orally bioavailable MET tyrosine kinase (hepatocyte growth factor receptor) inhibitor with potential antineoplastic activity. Its discovery is described by Schroeder et al. (2009) [1] where it is compound 10. It also has significant activity against other receptor tyrosine kinases, with details presented in the Biological activity tab..