Ligand id: 8259

Name: CM-352

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 8
Topological polar surface area 142.21
Molecular weight 487.18
XLogP 2.16
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
Hyperfibrinolysis causes excessive bleeding by destabilising clot formation, and represents a dangerous medical emergency. Antifibrinolytic agents are used to abrogate this type of bleeding. CM-352 acts as an antifibrinolytic by potently inhibiting MMP-10 and MMP-3 [2], two matrix metalloproteinases involved in the regulation of thrombus dissolution and extracellular matrix proteolysis [1,3-4].