Ligand id: 8259

Name: CM-352

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 8
Topological polar surface area 142.21
Molecular weight 487.18
XLogP 2.16
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Orbe J, Barrenetxe J, Rodriguez JA, Vivien D, Orset C, Parks WC, Birkland TP, Serrano R, Purroy A, Martinez de Lizarrondo S et al.. (2011)
Matrix metalloproteinase-10 effectively reduces infarct size in experimental stroke by enhancing fibrinolysis via a thrombin-activatable fibrinolysis inhibitor-mediated mechanism.
Circulation, 124 (25): 2909-19. [PMID:22104553]
2. Orbe J, Rodríguez JA, Sánchez-Arias JA, Salicio A, Belzunce M, Ugarte A, Chang HC, Rabal O, Oyarzabal J, Páramo JA. (2015)
Discovery and safety profiling of a potent preclinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the prevention and treatment of hemorrhage.
J. Med. Chem., 58 (7): 2941-57. [PMID:25686022]
3. Rodríguez JA, Sobrino T, Orbe J, Purroy A, Martínez-Vila E, Castillo J, Páramo JA. (2013)
proMetalloproteinase-10 is associated with brain damage and clinical outcome in acute ischemic stroke.
J. Thromb. Haemost., 11 (8): 1464-73. [PMID:23742289]
4. Suzuki Y, Nagai N, Umemura K, Collen D, Lijnen HR. (2007)
Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in mice.
J. Thromb. Haemost., 5 (8): 1732-9. [PMID:17596135]