Ligand id: 8475

Name: AZ628

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 85.23
Molecular weight 451.2
XLogP 4.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
The Ras/Raf/MEK/ERK pathway has been reported to contribute to the tumourigenic phenotype by inducing immortalisation, growth factor-independent growth, insensitivity to growth-inhibitory signals, ability to invade and metastasis, stimulating angiogenesis and inhibition of apoptosis [2]. The Raf kinases act as proto-oncogenes near the top of this pathway, and are being investigated as molecular targets for pharmacological inhibition in cancer.