Ligand id: 8475

Name: AZ628

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 85.23
Molecular weight 451.2
XLogP 4.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Khazak V, Astsaturov I, Serebriiskii IG, Golemis EA. (2007)
Selective Raf inhibition in cancer therapy.
Expert Opin. Ther. Targets, 11 (12): 1587-609. [PMID:18020980]
2. Kolch W, Kotwaliwale A, Vass K, Janosch P. 
The role of Raf kinases in malignant transformation.
Accessed on 24/06/2015. Modified on 24/06/2015.,
3. Wenglowsky S, Ren L, Grina J, Hansen JD, Laird ER, Moreno D, Dinkel V, Gloor SL, Hastings G, Rana S et al.. (2014)
Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase.
Bioorg. Med. Chem. Lett., 24 (8): 1923-7. [PMID:24675381]