Ligand id: 8527

Name: AZD8186

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 71.11
Molecular weight 457.18
XLogP 2.64
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
AZD8186 in combination with the anti-androgenic drug abiraterone, is being evaluated in clinical trial as a potential treatment for prostate cancer. The two compounds block complementary molecular pathways in prostate cancer, providing synergistic activity.