compound 15c [PMID: 21536437]

Ligand id: 8553

Name: compound 15c [PMID: 21536437]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 106.61
Molecular weight 539.22
XLogP 4.05
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
Aggrecanase inhibitors are hypothesised to have the potential to reduce the pathological cartilage catabolism observed in patients with oeseoarthritis (OA), providing an alternative mechanistic approach to traditional anti-inflammatory therapy.