compound 15c [PMID: 21536437]

Ligand id: 8553

Name: compound 15c [PMID: 21536437]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 106.61
Molecular weight 539.22
XLogP 4.05
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. De Savi C, Pape A, Sawyer Y, Milne D, Davies C, Cumming JG, Ting A, Lamont S, Smith PD, Tart J et al.. (2011)
Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis.
Bioorg. Med. Chem. Lett.21 (11): 3301-6. [PMID:21536437]