Ligand id: 8913

Name: AMG-337

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 131.25
Molecular weight 404.12
XLogP 2.56
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
AMG-337 is in Phase II clinical trials evaluating its efficacy as an antineoplastic therapy for MET amplified solid tumours of the stomach and esophagus- see NCT02344810 and NCT02016534 for example.