Ligand id: 8913

Name: AMG-337

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 131.25
Molecular weight 404.12
XLogP 2.56
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Bode CM, Boezio AA, Albrecht BK, Bellon SF, Berry L, Broome MA, Choquette D, Dussault I, Lewis RT, Lin MH et al.. (2012)
Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors.
Bioorg. Med. Chem. Lett.22 (12): 4089-93. [PMID:22595176]
2. Boezio AA, Berry L, Albrecht BK, Bauer D, Bellon SF, Bode C, Chen A, Choquette D, Dussault I, Fang M et al.. (2009)
Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors.
Bioorg. Med. Chem. Lett.19 (22): 6307-12. [PMID:19819693]