Ligand id: 8919

Name: AR-67

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 99.96
Molecular weight 478.19
XLogP 3.67
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Phase I clinical trial results are reoprted in [1]. A Phase II trial (NCT01124539) in patients with glioblastoma multiforme is currently active.
Mechanism Of Action and Pharmacodynamic Effects
AR-76 exhibits potent in vitro DNA topoisomerase I (TOP1)-mediated DNA-damaging activity.