AR-67

Ligand id: 8919

Name: AR-67

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 99.96
Molecular weight 478.19
XLogP 3.67
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Synonyms
AR67 | compound 14 [PMID:11052802] | DB-67 | DB67 | silatecan
Database Links
CAS Registry No. 220913-32-6
ChEMBL Ligand CHEMBL412309
GtoPdb PubChem SID 310264700
PubChem CID 6712744
Search Google for chemical match using the InChIKey XUSKJHCMMWAAHV-SANMLTNESA-N
Search Google for chemicals with the same backbone XUSKJHCMMWAAHV
Search UniChem for chemical match using the InChIKey XUSKJHCMMWAAHV-SANMLTNESA-N
Search UniChem for chemicals with the same backbone XUSKJHCMMWAAHV
Comments
AR-67 is a synthetic, highly lipophilic derivative of the natural alkaloid camptothecin (PubChem CID 24360), with potential antineoplastic [3,5] and radiosensitizing activities [4]. The compound has improved physicochemical properties compared to other camptothecin-derived drugs (e.g. SN-38, the active metabolite of the anti-cancer drug irinotecan, and topotecan) [2].