plecanatide

Ligand id: 9069

Name: plecanatide

Structure and Physico-chemical Properties

2D Structure
No information available.
Summary of Clinical Use
Plecanatide was evaluated in several Phase III clinical trials in patients with chronic idiopathic constipation or IBS-C. Click here to link to ClinicalTrials.gov's list of Phase III plecanatide trials. In January 2017 plecanatide was FDA approved for the treatment of chronic idiopathic constipation (CIC) in adults.
Mechanism Of Action and Pharmacodynamic Effects
Aginist-induced activation of GC-C receptors stimulates intracellular production of cyclic guanosine monophosphate (cGMP). This leads to downstream activation of the cystic fibrosis transmembrane conductance regulator (CFTR), the apical ion channel responsible for efflux of chloride ions from enterocytes lining the GI tract. The net result is efflux of water into the intestinal lumen, thus ameliorating constipation and improving intestinal transit.