plecanatide

Ligand id: 9069

Name: plecanatide

Structure and Physico-chemical Properties

2D Structure
Classification
Compound class Peptide or derivative
Approved drug? Yes (FDA (2017))
International Nonproprietary Names
INN number INN
9367 plecanatide
Synonyms
[3-glutamic acid(D>E)]human uroguanylin | SP-304 | Trulance®
Database Links
ChEMBL Ligand CHEMBL2103867
PubChem CID 70693500
Search Google for chemical match using the InChIKey NSPHQWLKCGGCQR-DLJDZFDSSA-N
Search Google for chemicals with the same backbone NSPHQWLKCGGCQR
Search PubMed clinical trials plecanatide
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Search PubMed titles/abstracts plecanatide
Search UniChem for chemical match using the InChIKey NSPHQWLKCGGCQR-DLJDZFDSSA-N
Search UniChem for chemicals with the same backbone NSPHQWLKCGGCQR
Comments
Plecanatide is a synthetic analogue of uroguanylin, which is an agonist of the guanylate cyclase C (GC-C) receptor (GUCY2C) [3]. Activation of GC-C in mucosal epithelial cells of the gastrointestinal tract (GI) tract causes the secretion of fluid, facilitating bowel movements. Plecanatide has potential to help manage constipating GI disorders, such as chronic idiopathic constipation and constipation-predominant irritable bowel syndrome (IBS-C). Plecanatide is one of the peptides claimed in patent WO2014151206, where it is represented by SEQ ID NO: 1 and code SP-304, with residue 3 (Aad) being gultamic acid (E, Glu) [2].
The SMILES and structure image used in this entry are from Chemicalize.
HELM notation is PEPTIDE1{N.D.E.C.E.L.C.V.N.V.A.C.T.G.C.L}$PEPTIDE1,PEPTIDE1,12:R3-4:R3|PEPTIDE1,PEPTIDE1,15:R3-7:R3$$$