Ligand id: 9174

Name: altiratinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 109.42
Molecular weight 510.15
XLogP 5.13
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
The US FDA has granted altiratinib Orphan Drug Designation for glioblastoma multiforme (GBM). Phase 1 clinical trial NCT02228811, is designed to evaluate oral altiratinib monotherapy vs. various locally advanced and metastatic solid tumours.