clofazimine

Ligand id: 9184

Name: clofazimine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 27.63
Molecular weight 472.12
XLogP 7.97
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Clofazimine is used in combination with the antibiotics, rifampicin and dapsone, as multidrug therapy (MDT) for the treatment of leprosy [1]. It is on the World Health Organization's List of Essential Medicines (link to 2015 list). It is not commercially available in the US, but can been obtained when required from the National Hansen's Disease (Leprosy) Program (NHDP) of the US Department of Health and Human Services [3].
Mechanism Of Action and Pharmacodynamic Effects
Clofazimine inhibits bacterial DNA replication and proliferation[1].
External links