telotristat ethyl

Ligand id: 9490

Name: telotristat ethyl

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 131.17
Molecular weight 574.17
XLogP 6.32
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
FDA approved (in combination with somatostatin analog therapy) for the treament of carcinoid syndrome diarrhea in patients with metastatic neuroendocrine tumors [2-3].
Mechanism Of Action and Pharmacodynamic Effects
Telotristat acts as a serotonin synthesis inhibitor, and this effect opposes inflammation in the gut [1,4].