telotristat ethyl

Ligand id: 9490

Name: telotristat ethyl

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 131.17
Molecular weight 574.17
XLogP 6.32
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Kim JJ, Wang H, Terc JD, Zambrowicz B, Yang QM, Khan WI. (2015)
Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation.
Am. J. Physiol. Gastrointest. Liver Physiol., 309 (6): G455-65. [PMID:26206858]
2. Kulke MH, Hörsch D, Caplin ME, Anthony LB, Bergsland E, Öberg K, Welin S, Warner RR, Lombard-Bohas C, Kunz PL et al.. (2017)
Telotristat Ethyl, a Tryptophan Hydroxylase Inhibitor for the Treatment of Carcinoid Syndrome.
J. Clin. Oncol., 35 (1): 14-23. [PMID:27918724]
3. Lamarca A, Barriuso J, McNamara MG, Hubner RA, Valle JW. (2016)
Telotristat ethyl: a new option for the management of carcinoid syndrome.
Expert Opin Pharmacother, 17 (18): 2487-2498. [PMID:27817224]
4. Margolis KG, Stevanovic K, Li Z, Yang QM, Oravecz T, Zambrowicz B, Jhaver KG, Diacou A, Gershon MD. (2014)
Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine.
Gut, 63 (6): 928-37. [PMID:23749550]