hsp60

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Ligands
hsp60 (Human)

GtoPdb Ligand ID: 4953

Synonyms: heat shock 60kD protein 1 (chaperonin) | HSP-60 | mitochondrial matrix protein P1

Compound class: Endogenous peptide in human, mouse or rat

Comment: HSP60 is a mitochondrial chaperone that is upregulated by immune activation. It is a highly conserved protein, which acts as a major immune modulator in the control of the innate and adaptive immune systems in mammals [1-2].

Species: Human

Summary
Biological activity
References
Structure
Immunopharmacology

Immunopharmacology Comments
HSP60 acts as an immune modulator in the control of the innate and adaptive immune systems in mammals [2]. A humanized anti-HSP60 monoclonal (prozumab) has been engineered, and it is predicted to have therapeutic potential for the treatment of human autoimmune inflammatory diseases, based on results from rodent disease models and human cell line studies [3].

Immunopharmacology Comments

HSP60 acts as an immune modulator in the control of the innate and adaptive immune systems in mammals [2]. A humanized anti-HSP60 monoclonal (prozumab) has been engineered, and it is predicted to have therapeutic potential for the treatment of human autoimmune inflammatory diseases, based on results from rodent disease models and human cell line studies [3].