brentuximab vedotin

Ligand id: 6772

Name: brentuximab vedotin

Immunopharmacology Comments
Brentuximab vedotin is an ADC targeting CD-30 positive tumour cells.
Immunopharmacology Disease
Disease X-Refs Comment References
Systemic scleroderma Disease Ontology: DOID:418
OMIM: 181750
Orphanet: ORPHA90291
Phase 1/2 clinical candidate for systemic sclerosis- see NCT03222492 and NCT03198689
Mastocytosis Disease Ontology: DOID:350
Phase 2 clinical candidate for aggressive systemic mastocytosis, mast cell leukemia and systemic mastocytosis- see NCT01807598
Systemic lupus erythematosus Disease Ontology: DOID:9074
OMIM: 152700
Orphanet: ORPHA536
Ex Phase 2 clinical candidate for adults with SLE- trial NCT02533570 was terminated
Mycosis fungoides OMIM: 254400
Orphanet: ORPHA2584
Approved drug for CD-30 positive MF. 3
Anaplastic large cell lymphoma Disease Ontology: DOID:0050744
Approved drug for systemic anaplastic large cell lymphoma, and primary cutaneous ALCL.
Lymphoma, Hodgin, Classic; CHL Disease Ontology: DOID:8567
OMIM: 236000
Approved drug for HL.