brentuximab vedotin

Ligand id: 6772

Name: brentuximab vedotin

References
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Functional effects of CD30 on a large granular lymphoma cell line, YT. Inhibition of cytotoxicity, regulation of CD28 and IL-2R, and induction of homotypic aggregation.
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immunotherapy; fusion proteins; antitumor agents; for treatment and prevention of hodgkin's disease.
Patent number: US7090843. Assignee: Seattle Genetics, Inc. Priority date: 09/12/2014. Publication date: 15/08/2006.
3. Mitra A, Sept D. (2004)
Localization of the antimitotic peptide and depsipeptide binding site on beta-tubulin.
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4. Moskowitz CH, Nademanee A, Masszi T, Agura E, Holowiecki J, Abidi MH, Chen AI, Stiff P, Gianni AM, Carella A et al.. (2015)
Brentuximab vedotin as consolidation therapy after autologous stem-cell transplantation in patients with Hodgkin's lymphoma at risk of relapse or progression (AETHERA): a randomised, double-blind, placebo-controlled, phase 3 trial.
Lancet,  [Epub ahead of print]. [PMID:25796459]