brentuximab vedotin

Ligand id: 6772

Name: brentuximab vedotin

1. Bowen MA, Olsen KJ, Cheng L, Avila D, Podack ER. (1993)
Functional effects of CD30 on a large granular lymphoma cell line, YT. Inhibition of cytotoxicity, regulation of CD28 and IL-2R, and induction of homotypic aggregation.
J. Immunol., 151 (11): 5896-906. [PMID:8245437]
2. Connors JM, Jurczak W, Straus DJ, Ansell SM, Kim WS, Gallamini A, Younes A, Alekseev S, Illés Á, Picardi M et al.. (2018)
Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's Lymphoma.
N. Engl. J. Med., 378 (4): 331-344. [PMID:29224502]
3. FDA. 
FDA approves Brentuximab vedotin for the treatment of adult patients with primary cutaneous anaplastic large cell lymphoma.
Accessed on 10/11/2017. Modified on 10/11/2017.,
4. Francisco JA, Risdon G, Wahl AF, Siegall C. (2006)
immunotherapy; fusion proteins; antitumor agents; for treatment and prevention of hodgkin's disease.
Patent number: US7090843. Assignee: Seattle Genetics, Inc. Priority date: 09/12/2014. Publication date: 15/08/2006.
5. Mitra A, Sept D. (2004)
Localization of the antimitotic peptide and depsipeptide binding site on beta-tubulin.
Biochemistry, 43 (44): 13955-62. [PMID:15518544]
6. Moskowitz CH, Nademanee A, Masszi T, Agura E, Holowiecki J, Abidi MH, Chen AI, Stiff P, Gianni AM, Carella A et al.. (2015)
Brentuximab vedotin as consolidation therapy after autologous stem-cell transplantation in patients with Hodgkin's lymphoma at risk of relapse or progression (AETHERA): a randomised, double-blind, placebo-controlled, phase 3 trial.
Lancet, 385 (9980): 1853-62. [PMID:25796459]
7. Younes A, Connors JM, Park SI, Fanale M, O'Meara MM, Hunder NN, Huebner D, Ansell SM. (2013)
Brentuximab vedotin combined with ABVD or AVD for patients with newly diagnosed Hodgkin's lymphoma: a phase 1, open-label, dose-escalation study.
Lancet Oncol., 14 (13): 1348-56. [PMID:24239220]