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Synonyms: Hu23F2G | LeukArrest
Compound class:
Antibody
Comment: Rovelizumab (Hu23F2G) is a humanized IgG4 bispecific monoclonal antibody targeting integrin alpha L subunit (ITGAL, CD11A) and integrin beta 2 subunit (ITGB2, CD18) [5], which are components of the leukocyte adhesion integrin LFA-1. Rovelizumab was developed by Icos Corporation (later acquired by Eli Lilly) for potential use in multiple sclerosis, myocardial infarction and ischemic stroke.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. |
| Immunopharmacology Comments |
| Experimental models suggest that β2-integrins play a role in demyelinating disease [1]. |
