rovelizumab

Home
Ligands
rovelizumab

GtoPdb Ligand ID: 9598

Synonyms: Hu23F2G | LeukArrest

Comment: Rovelizumab (Hu23F2G) is a humanized IgG4 bispecific monoclonal antibody targeting integrin alpha L subunit (ITGAL, CD11A) and integrin beta 2 subunit (ITGB2, CD18) [5], which are components of the leukocyte adhesion integrin LFA-1. Rovelizumab was developed by Icos Corporation (later acquired by Eli Lilly) for potential use in multiple sclerosis, myocardial infarction and ischemic stroke.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

References
1. Hu X, Wohler JE, Dugger KJ, Barnum SR. (2010) beta2-integrins in demyelinating disease: not adhering to the paradigm. J Leukoc Biol, 87 (3): 397-403. [PMID:20007244]
2. Liles WC, Dale DC, Price TH, Gaviria JM, Turner T, Saoud J, Frumkin LR. (2000) Inhibition of in vivo neutrophil transmigration by a novel humanized anti-CD11/CD18 monoclonal antibody. Cytokines Cell Mol Ther, 6 (3): 121-6. [PMID:11140880]
3. Mazzone A, Ricevuti G. (1995) Leukocyte CD11/CD18 integrins: biological and clinical relevance. Haematologica, 80 (2): 161-75. [PMID:7628754]
4. Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R, Luscinskas FW. (2005) ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow. Blood, 106 (2): 584-92. [PMID:15811956]
5. Yenari MA, Kunis D, Sun GH, Onley D, Watson L, Turner S, Whitaker S, Steinberg GK. (1998) Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia. Exp Neurol, 153 (2): 223-33. [PMID:9784282]

References

1. Hu X, Wohler JE, Dugger KJ, Barnum SR. (2010)
beta2-integrins in demyelinating disease: not adhering to the paradigm.
J Leukoc Biol, 87 (3): 397-403. [PMID:20007244]

2. Liles WC, Dale DC, Price TH, Gaviria JM, Turner T, Saoud J, Frumkin LR. (2000)
Inhibition of in vivo neutrophil transmigration by a novel humanized anti-CD11/CD18 monoclonal antibody.
Cytokines Cell Mol Ther, 6 (3): 121-6. [PMID:11140880]

3. Mazzone A, Ricevuti G. (1995)
Leukocyte CD11/CD18 integrins: biological and clinical relevance.
Haematologica, 80 (2): 161-75. [PMID:7628754]

4. Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R, Luscinskas FW. (2005)
ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow.
Blood, 106 (2): 584-92. [PMID:15811956]

5. Yenari MA, Kunis D, Sun GH, Onley D, Watson L, Turner S, Whitaker S, Steinberg GK. (1998)
Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia.
Exp Neurol, 153 (2): 223-33. [PMID:9784282]