oxymetazoline

Ligand id: 124

Name: oxymetazoline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 44.62
Molecular weight 260.19
XLogP 3.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
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High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action.
J Neurochem72: 2127-2134. [PMID:10217294]
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Selectivity of the imidazoline alpha-adrenoceptor agonists (oxymetazoline and cirazoline) for human cloned alpha 1-adrenoceptor subtypes.
Br. J. Pharmacol.116 (1): 1611-8. [PMID:8564227]
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Ligand efficacy and potency at recombinant alpha 2 adrenergic receptors - Agonist-mediated [35S]GTPgammaS binding.
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Gene targeting--homing in on alpha 2-adrenoceptor-subtype function.
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Selectivity of agonists for cloned α1-adrenergic receptor subtypes.
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NS-49, a novel alpha-1a adrenoceptor selective agonist characterization using recombinant human alpha-1 adrenoceptors.
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KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues.
Mol. Pharmacol.48: 250-258. [PMID:7651358]
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Microphysiometric analysis of human alpha1a-adrenoceptor expressed in Chinese hamster ovary cells.
Br J Pharmacol127: 962-968. [PMID:10433504]
10. UhlĂ©n S, Porter AC, Neubig RR. (1994)
The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors.
J Pharmacol Exp Ther271: 1558-1565. [PMID:7996470]