Ligand id: 1456

Name: erythromycin-A

Abbreviated name: EM-A

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 14
Hydrogen bond donors 5
Rotatable bonds 7
Topological polar surface area 193.91
Molecular weight 733.46
XLogP 1.14
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Feighner SD, Tan CP, McKee KK, Palyha OC, Hreniuk DL, Pong SS, Austin CP, Figueroa D, MacNeil D, Cascieri MA, Nargund R, Bakshi R, Abramovitz M, Stocco R, Kargman S, O'Neill G, Van der Ploeg LH, Evans J, Patchett AA, Smith RG, Howard AD. (1999)
Receptor for motilin identified in the human gastrointestinal system.
Science, 284: 2184-2188. [PMID:10381885]
2. Thielemans L, Depoortere I, Perret J, Robberecht P, Liu Y, Thijs T, Carreras C, Burgeon E, Peeters TL. (2005)
Desensitization of the human motilin receptor by motilides.
J Pharmacol Exp Ther, 313: 1397-1405. [PMID:15764739]