levocabastine

Ligand id: 1586

Name: levocabastine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 64.33
Molecular weight 420.22
XLogP 6.18
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Botto JM, Chabry J, Sarret P, Vincent JP, Mazella J. (1998)
Stable expression of the mouse levocabastine-sensitive neurotensin receptor in HEK 293 cell line: binding properties, photoaffinity labeling, and internalization mechanism.
Biochem Biophys Res Commun243: 585-590. [PMID:9480852]
2. Chalon P, Vita N, Kaghad M, Guillemot M, Bonnin J, Delpech B, Le Fur G, Ferrara P, Caput D. (1996)
Molecular cloning of a levocabastine-sensitive neurotensin binding site.
FEBS Lett386: 91-94. [PMID:8647296]
3. Mazella J, Botto JM, Guillemare E, Coppola T, Sarret P, Vincent JP. (1996)
Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain.
J Neurosci16: 5613-5620. [PMID:8795617]
4. Richard F, Barroso S, Martinez J, Labbé-Jullié C, Kitabgi P. (2001)
Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2.
Mol Pharmacol60: 1392-1398. [PMID:11723247]
5. Schotte A, Leysen JE, Laduron PM. (1986)
Evidence for a displaceable non-specific [3H]neurotensin binding site in rat brain.
Naunyn Schmiedebergs Arch. Pharmacol.333 (4): 400-5. [PMID:3022160]