Ligand id: 1958

Name: bimatoprost

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 13
Topological polar surface area 89.79
Molecular weight 415.27
XLogP 5.18
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Camras CB, Sharif NA, Wax MB, Stjernschantz J. (2008)
Bimatoprost, the prodrug of a prostaglandin analogue.
Br J Ophthalmol, 92 (6): 862-3; author reply 863-4. [PMID:18523093]
2. Davies SS, Ju WK, Neufeld AH, Abran D, Chemtob S, Roberts 2nd LJ. (2003)
Hydrolysis of bimatoprost (Lumigan) to its free acid by ocular tissue in vitro.
J Ocul Pharmacol Ther, 19 (1): 45-54. [PMID:12648303]
3. Woodward DF, Krauss AH, Chen J, Liang Y, Li C, Protzman CE, Bogardus A, Chen R, Kedzie KM, Krauss HA, Gil DW, Kharlamb A, Wheeler LA, Babusis D, Welty D, Tang-Liu DD, Cherukury M, Andrews SW, Burk RM, Garst ME. (2003)
Pharmacological characterization of a novel antiglaucoma agent, Bimatoprost (AGN 192024).
J Pharmacol Exp Ther, 305: 772-785. [PMID:12606640]