clotrimazole

Ligand id: 2330

Name: clotrimazole

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 17.82
Molecular weight 344.11
XLogP 8.56
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction.
Proc. Natl. Acad. Sci. U.S.A.95 (21): 12208-13. [PMID:9770465]
2. Ghanshani S, Coleman M, Gustavsson P, Wu AC, Gargus JJ, Gutman GA, Dahl N, Mohrenweiser H, Chandy KG. (1998)
Human calcium-activated potassium channel gene KCNN4 maps to chromosome 19q13.2 in the region deleted in diamond-blackfan anemia.
Genomics51 (1): 160-1. [PMID:9693050]
3. Hill K, McNulty S, Randall AD. (2004)
Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole.
Naunyn Schmiedebergs Arch. Pharmacol.370 (4): 227-37. [PMID:15549272]
4. Ishii TM, Silvia C, Hirschberg B, Bond CT, Adelman JP, Maylie J. (1997)
A human intermediate conductance calcium-activated potassium channel.
Proc. Natl. Acad. Sci. U.S.A.94 (21): 11651-6. [PMID:9326665]
5. Kanno Y, Tanuma N, Takahashi A, Inouye Y. (2013)
TO901317, a potent LXR agonist, is an inverse agonist of CAR.
J Toxicol Sci38 (3): 309-15. [PMID:23665929]
6. Logsdon NJ, Kang J, Togo JA, Christian EP, Aiyar J. (1997)
A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes.
J. Biol. Chem.272 (52): 32723-6. [PMID:9407042]
7. Moore LB, Parks DJ, Jones SA, Bledsoe RK, Consler TG, Stimmel JB, Goodwin B, Liddle C, Blanchard SG, Willson TM, Collins JL, Kliewer SA. (2000)
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.
J. Biol. Chem.275 (20): 15122-7. [PMID:10748001]
8. Nina DUllrich. (2005)
PhD Thesis.  in  TRPM4 and TRPM5: Functional characterisation and comparison of two novel Ca2+-activated cation channels of the TRPM subfamily Faculteit Geneeskunde, Dept. Moleculaire Celbiologie, KU Leuven.  
9. Wulff H, Miller MJ, Hansel W, Grissmer S, Cahalan MD, Chandy KG. (2000)
Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant.
Proc. Natl. Acad. Sci. U.S.A.97 (14): 8151-6. [PMID:10884437]