clotrimazole

Ligand id: 2330

Name: clotrimazole

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 17.82
Molecular weight 344.11
XLogP 8.56
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
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Target Type Action Affinity Units Concentration range (M) Reference
TRPM2 Channel blocker Antagonist - - 3x10-6 - 3x10-5 3
Conc range: 3x10-6 - 3x10-5 M [3]
Voltage: -60.0 – -15.0 mV
TRPM4 Gating inhibitor Antagonist - - 1x10-6 - 1x10-5 8
Conc range: 1x10-6 - 1x10-5 M [8]
Voltage: 100.0 mV
KCa3.1 Channel blocker Inhibition 6.4 – 7.6 pKd - 2,4,6,9
pKd 6.4 – 7.6 [2,4,6,9]
TRPM8 Channel blocker - - - -
Selectivity at human nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Constitutive androstane receptor Antagonist Antagonist 6.2 pIC50 - 7
pIC50 6.2 [7]
Pregnane X receptor Agonist Agonist - - - 1
[1]
Targets where the ligand is described in the comment field
Target Comment
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