clotrimazole

Ligand id: 2330

Name: clotrimazole

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: clotrimazole

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 17.82
Molecular weight 344.11
XLogP 8.56
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
TRPM2 Hs Channel blocker Antagonist - - 3x10-6 - 3x10-5 3
Conc range: 3x10-6 - 3x10-5 M [3]
Voltage: -60.0 – -15.0 mV
TRPM4 Hs Gating inhibitor Antagonist - - 1x10-6 - 1x10-5 8
Conc range: 1x10-6 - 1x10-5 M [8]
Voltage: 100.0 mV
KCa3.1 Hs Channel blocker Inhibition 6.4 – 7.6 pKd - 2,4,6,9
pKd 6.4 – 7.6 [2,4,6,9]
TRPM8 Hs Channel blocker - - - -
Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Constitutive androstane receptor Hs Antagonist Antagonist 6.2 pIC50 - 7
pIC50 6.2 [7]
Pregnane X receptor Hs Agonist Agonist - - - 1
[1]
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields