Ligand id: 2507

Name: clofilium

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 13
Topological polar surface area 0
Molecular weight 338.26
XLogP 7.64
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. de Los Angeles Tejada M, Stolpe K, Meinild AK, Klaerke DA. (2012)
Clofilium inhibits Slick and Slack potassium channels.
Biologics, 6: 465-70. [PMID:23271893]
2. Gessner G, Heinemann SH. (2003)
Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241.
Br. J. Pharmacol., 138 (1): 161-71. [PMID:12522086]
3. Malayev AA, Nelson DJ, Philipson LH. (1995)
Mechanism of clofilium block of the human Kv1.5 delayed rectifier potassium channel.
Mol. Pharmacol., 47 (1): 198-205. [PMID:7838129]
4. Niemeyer MI, Cid LP, Barros LF, SepĂșlveda FV. (2001)
Modulation of the two-pore domain acid-sensitive K+ channel TASK-2 (KCNK5) by changes in cell volume.
J. Biol. Chem., 276 (46): 43166-74. [PMID:11560934]