Ligand id: 587

Name: candesartan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 118.81
Molecular weight 440.16
XLogP 6.89
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Storka A, Vojtassakova E, Mueller M, Kapiotis S, Haider DG, Jungbauer A, Wolzt M. (2008)
Angiotensin inhibition stimulates PPARgamma and the release of visfatin.
Eur. J. Clin. Invest., 38 (11): 820-6. [PMID:19021699]
2. Vanderheyden PML, Fierens FLP, De Backer JP, Frayman N, Vauquelin G. (1999)
Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin II AT1 receptors.
Br. J. Pharmacol., 126: 1057-1065. [PMID:10193788]