IL-17B

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Ligands
IL-17B (Human)

GtoPdb Ligand ID: 5877

Compound class: Endogenous peptide in human, mouse or rat

Comment: IL-17B is a proinflammatory homolog of IL-17 expressed at very high levels in spinal cord (primarily localizing to neuronal cell bodies and axons) and at lower levels in trachea, prostate, lung, small intestine, testes, adrenal, and pancreas [2-3], and acting on a restricted set of target cells (IL-17B receptor expression is restricted to human kidney, pancreas, liver, brain, and intestines [3]).

Species: Human

References
1. Alinejad V, Dolati S, Motallebnezhad M, Yousefi M. (2017) The role of IL17B-IL17RB signaling pathway in breast cancer. Biomed Pharmacother, 88: 795-803. [PMID:28160754]
2. Moore EE, Presnell S, Garrigues U, Guilbot A, LeGuern E, Smith D, Yao L, Whitmore TE, Gilbert T, Palmer TD et al.. (2002) Expression of IL-17B in neurons and evaluation of its possible role in the chromosome 5q-linked form of Charcot-Marie-Tooth disease. Neuromuscul Disord, 12 (2): 141-50. [PMID:11738356]
3. Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL et al.. (2000) A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity. J Biol Chem, 275 (25): 19167-76. [PMID:10749887]
4. Wu HH, Hwang-Verslues WW, Lee WH, Huang CK, Wei PC, Chen CL, Shew JY, Lee EY, Jeng YM, Tien YW et al.. (2015) Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines. J Exp Med, 212 (3): 333-49. [PMID:25732306]

References

1. Alinejad V, Dolati S, Motallebnezhad M, Yousefi M. (2017)
The role of IL17B-IL17RB signaling pathway in breast cancer.
Biomed Pharmacother, 88: 795-803. [PMID:28160754]

2. Moore EE, Presnell S, Garrigues U, Guilbot A, LeGuern E, Smith D, Yao L, Whitmore TE, Gilbert T, Palmer TD et al.. (2002)
Expression of IL-17B in neurons and evaluation of its possible role in the chromosome 5q-linked form of Charcot-Marie-Tooth disease.
Neuromuscul Disord, 12 (2): 141-50. [PMID:11738356]

3. Shi Y, Ullrich SJ, Zhang J, Connolly K, Grzegorzewski KJ, Barber MC, Wang W, Wathen K, Hodge V, Fisher CL et al.. (2000)
A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity.
J Biol Chem, 275 (25): 19167-76. [PMID:10749887]

4. Wu HH, Hwang-Verslues WW, Lee WH, Huang CK, Wei PC, Chen CL, Shew JY, Lee EY, Jeng YM, Tien YW et al.. (2015)
Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines.
J Exp Med, 212 (3): 333-49. [PMID:25732306]