Ligand id: 6432

Name: camostat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 137.31
Molecular weight 398.16
XLogP 2.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Rowe SM, Reeves G, Hathorne H, Solomon GM, Abbi S, Renard D, Lock R, Zhou P, Danahay H, Clancy JP et al.. (2013)
Reduced sodium transport with nasal administration of the prostasin inhibitor camostat in subjects with cystic fibrosis.
Chest, 144 (1): 200-7. [PMID:23412700]
2. Senokuchi K, Nakai H, Nakayama Y, Odagaki Y, Sakaki K, Kato M, Maruyama T, Miyazaki T, Ito H, Kamiyasu K et al.. (1995)
New orally active serine protease inhibitors.
J. Med. Chem., 38 (14): 2521-3. [PMID:7629790]